Latest News

Julie Vrana is the lead author on a recently accepted paper, “Forecasting cell death dose-response from early signal transduction responses in vitro”.

Jonathan Boyd and Julie Vrana recently presented their research at the Drug Safety Gordon Research Conference. Presentations included: “An in vitro approach to predict cytotoxicity of chemical mixtures” and “An approach to forecast cytotoxicity”. Many thanks to GRC for sponsoring us!

Jonathan Boyd, Julie Vrana, and Alice Han recently presented their research at the National Society of Toxicology Meeting in Phoenix, AZ. Presentations included “Forecasting Cell Death Dose-Response from Early Signal Transduction Responses In Vitro”, “A Graph Theoretical Approach to Determine In Vitro Mode of Action”, and “An Approach to Investigate Intracellular Protein Network Responses”.

Holly Currie recently successfully defended her dissertation entitled, Analysis and Interpretation of Complex Biological Signal Transduction Networks. Congratulations Holly!

Holly Currie is the lead author on a recently accepted paper, “An approach to investigate intracellular protein network responses”. Chemical Research in Toxicology 2014

Holly Currie is the lead author on a recently accepted paper, “Spatial cytokine distribution following traumatic injury”. Cytokine 2014

Jonathan Boyd received the 2013 Early Career Innovator Award from West Virginia University.

Julie Vrana has a recently accepted paper, “Amelioration of an undesired action of deguelin” Toxicon 2013

Julie Vrana was the recipient of a John R. Conard Fellowship for the 2013-2014 academic year. Congratulations!

Alice Han was the recipient of a C. Eugene Bennett Fellowship for the 2013-2014 academic year. Congratulations!

Jonathan Boyd recently served on the U.S. EPA Science to Achieve Results (STAR) Graduate Fellowship review panel.

Jonathan Boyd, Julie Vrana, and Holly Williams are co-authors on a recently accepted paper, “In vitro approach to predict post-translational phosphorylation response to mixtures. Toxicology 2013

Jonathan Boyd receives funding to understand human responses to stress. Research funded under this DARPA award will be focused on finding a measure of human entropy to improve the overall capabilities of individuals and groups when under duress. Announcement

Holly Williams was lead author on a paper, “Spatial cytokine distribution following traumatic injury: Potential predictive biomarkers of tissue viability” that recently won Best Paper for West Virginia State American College of Surgeons.

Jonathan Boyd, Holly Williams, and Julie Vrana recently presented their research at the National Society of Toxicology Meeting in San Francisco, CA. Presentations included “Identification of early signal transduction responses predictive of survival”, “Dose-response analysis of stress response signal transduction networks”, and “Estimation of key temporal response to determine critical signaling events”.

Jonathan Boyd won an award for the Best Intellectual Property Idea of the Evening at the Linking Innovation, Industry and Commercialization Defense-related event.

Jonathan Boyd received funds from the Brodie Discovery and Innovation Fund to study predictive biomarkers of tissue viability post-traumatic injury.

Jonathan Boyd and Holly Williams were co-authors on a recently accepted paper, “Exploring the boundaries of Additivity: mixtures of NADH-quinone oxidoreductase (complex I) inhibitors”.Chem Res Toxicol 2011

Holly Williams was awarded the 2010-2011 John H. Trotter Graduate Chemistry Scholarship. Congratulations Holly!

Jonathan Boyd received the Mixtures Specialty Section Best Abstract Award for “Cell Signal Transduction to Predict Mixture Interactions” at the SOT meeting in Washington, DC.

Xueli Gao presented “Pifithrin increases IGF-1R Inhibitor-Mediated HepG2 Hepatocarcinoma Death” at the SOT meeting in Washington, DC. Catherine Kinzer also presented her findings regarding “Alterations of Signaling Protein Interactions to Increasing Dose” at the meeting. Finally, Amber Cook presented her research entitled, “Impact of Energy Metabolism on the Design of Kinase-Targeted Therapeutics”

Jonathan Boyd was a co-author of a paper entitled, “Capillary Column Gas Chromatographic-Mass Spectometric Determination of the Organophosphate Nerve Agent Surrogate Dimethyl Methylphosphonate in Gaseous Phase”. Talanta 2010

A new book entitled Quantitative Modeling in Toxicology was recently released and contains a chapter co-authored by Jonathan Boyd. Physiologically-based modeling of pharmacokinetic interactions in chemical mixtures (Haddad, Tardif, Boyd, Krishnan).

Jonathan Boyd presented “Prediction of Mixture Interactions via Cellular Stress Response” at the Fall 2010 National ACS meeting in Boston, MA. He also presented with Cat Kinzer and Holly Williams for their research, “Estimating the Interactions of Signaling Proteins in Response to Increasing Dose.”

Amber Cook received first place in the Biological Sciences division of the WVU Summer Undergraduate Research Symposium for her research, “the impact of glycolysis on the design of kinase-targeted chemotherapeutics.” Way to go Amber!

Amber poster honors SURE 2010

Amber Cook has been named a 2010 Honors SURE awardee to further her research on the potential toxicity of kinase inhibitors. Congratulations Amber!

Two new book chapters co-authored by Jonathan Boyd were recently released in General and Applied Toxicology, 3rd Edition (Wiley & Sons, Ltd). Toxicology of Chemical Mixtures (Krishnan and Boyd); Evaluation of Toxicological Interactions for the Dose-Response Assessment of Chemical Mixtures (Krishnan, Isukapalli, Boyd)

Jonathan Boyd receives DARPA YFA Award. The Natural Designs for Network Threats program funded under this DARPA award will use signal transduction networks to understand the threat assessment decision process of cells in response to toxic exposures. Identifying key mechanistic features and cellular network strategies (e.g. localization, amplification, proper weighting, and significance of a threat) could greatly enhance future information network systems and software applications by incorporating novel “secure by design” techniques learned from nature. Announcement

Stanley Strawbridge is announced as a 2009 Department of Homeland Security Scholar. Congratulations Stan!

Jonathan Boyd and Holly Williams presented “Dynamic In Vitro Approach to Prediction of Mixtures Interactions” at the 16th Annual North American ISSX meeting in Baltimore, MD. The two teamed up with Stanley Strawbridge to also present “Monitoring Metabolic Adaptation of HepG2 cells to Achieve New Steady State of Oxygen Consumption” at the meeting.

Jonathan Boyd presented some of his research toward the development of high-throughput screens for improved toxicity predictions to a group of researchers at NIOSH this summer.

A book chapter co-authored by Jonathan Boyd in Advances in Biological and Chemical Terrorism Countermeasures (CRC Press) has been released. Sensing Biological and Chemical Threat Agents (Coimbatore, Cobb, Boyd, Marsland, Presley).

Jonathan Boyd was the keynote speaker at the TIEHH Spring Banquet at Texas Tech University in Lubbock, TX.


Too much fun at 2014 SOT
SOT MPI party boyd group

A mini-reunion at Holly’s wedding!

Having fun in the BIG XII!

Happy birthday Holly!!!
Hollys bday

Christmas is always special around here

We even have fun in the lab!